Day 1 :
Keynote Forum
Jun Sun
University of Illinois at Chicago, USA
Keynote: Vitamin D/Vitamin D receptor regulation of microbiome in inflammation and obesity
Time : 09:30-10:20
Biography:
Jun Sun is an Associate Professor at the University of Illinois at Chicago. She is a fellow of American Gastroenterological Associate. Her key achievements include characterization of vitamin D receptor regulation of microbiome in intestinal homeostasis and inflammation, identification of dysbiosis and intestinal dysfunction in ALS, and identification of bacteria in regulating intestinal stem cells. She has published over 120 scientific articles in peer-reviewed journals, including Cell Stem Cells, Nature Genetics, Gut and JBC. She is in the editorial board of 10 scientific journals. Her research is supported by the NIH, DOD and other awards.
Abstract:
Obesity occurs when there is an unfortunate combination of environment triggers, genetic susceptibility, and dysbiosis. A positive association between obesity and vitamin D deficiency have been found in human obesity for years, but determining cause and effect has been difficult. Majority of the biological function of vitamin D is regulated by vitamin D receptor (VDR). Our Nature Genetics paper has demonstrated that human VDR gene is a key host factor to shape gut microbiome. Further, we have demonstrated that intestinal epithelial VDR conditional knockout (VDRΔIEC) leads to dysbiosis (imbalanced microbiome). However, the study on biological function of VDR in obesity-associated dysbiosis and inflammation is still limited. In the current study, we showed that conditional removal of VDR in the intestinal epithelium made mice more susceptible to obesity. There are decreased genus Lactobacillus and butyrate-producing bacteria in the VDRΔIEC mice. Interestingly, the genus Lactobacillus was enriched on calorie-restricted low-fat diet. The butyrate-producing bacteria play an important role in blood glucose regulation and lipid metabolism. The dysbiosis observed in VDRΔIEC mice is very similar as the bacterial profile in obesity. Dysbiosis controls metabolic endotoxemia during obesity and bacterial factors, such as lipopolysaccharide (LPS). Our
data showed accumulated LPS in the blood of VDRΔIEC mice. Increased inflammation and insulin intolerance were found in the VDRΔIEC mice on high fat diet. Taken together, our study has demonstrated that VDR regulation of microbiome contributes to the development of obesity.
Keynote Forum
Sergio Wehinger
University of Talca, Chile
Keynote: Characterization of Caveolin-1 null mice in sensitization to lipotoxicity in murine pancreatic islets subjected to a high fat diet
Time : 10:20-11:10
Biography:
Sergio Wehinger has completed his PhD in Biomedical Sciences from University of Chile in 2013 and actually is the Director of Magister in Biomedical Sciences of University of Talca. He has published in more than 10 papers and currently he is investigating the molecular mechanisms involved in the cellular failure of the beta pancreatic islets, which is induced by elevated free fatty acids and oxidative stress levels, to elucidate how to abolish these processes.
Abstract:
Introduction: Elevated levels of fatty acids (FFA) induce cellular dysfunction, leading to a phenomenon known as “lipotoxicity”, which involves insulin resistance and beta pancreatic cell damage, events that has been observed in Metabolic Syndrome, favoring the development of type 2 diabetes mellitus (T2DM). Although several studies have addressed lipotoxicity in beta cells, many aspects of cellular pathways involved remain to be defined. We previously reported that the expression of the protein caveolin-1 (CAV1) promotes lipotixicity-induced apoptosis in vitro in a mouse beta cell line (Wehinger et al, 2015). However, if this phenomenon is pathophysiologically relevant in a whole organism, remains to be elucidated.
Strategy to address the problem: We evaluated the metabolic profile of C57BL/6J wild type (WT) and CAV1-null mice exposed to a High Fat Diet (HFD: 60% fat) for three months as well as the viability of pancreatic islets from these animals. We founded that CAV-1 null mice showed higher levels of triglycerides and cholesterol compared to WT mice, although null mice presented a better response to the glucose tolerance test. Finally, islets from CAV-1 null mice showed lower levels of apoptosis after HFD.
Conclusion: Although null mice showed a metabolic profile apparently more lipotoxic, they were more resistant to the deleterious effects on beta islets, accordingly with our previous results in vitro. Understanding the signaling pathways associated with FFA-induced beta cell demise could help to identify targets for advanced therapies in preventing T2DM derived from
Metabolic Syndrome.
Keynote Forum
ASM Giasuddin
Medical Research Unit (MRU), Bangladesh
Keynote: Effects of Laparoscopic Cholecystectomy on lipid profile and lipoprotein (A) status in bangladeshi patients with cholelithiasis
Time : 11:40-12:30
Biography:
ASM Giasuddin completed his MSc in Biochemistry from University of Dhaka, Bangladesh in 1969, He obtained PhD at the age of 27 years from University of London, UK in April 1976 and continued postdoctoral fellowships at London University until May 1982. He has been a Professor of Biochemistry and Immunology for the last 20 years since 1996 in various medical schools and universities in different countries. Presently, he is serving as Director of Medical Research Unit (MRU), The Medical and Health Welfare Trust (MHWT), Dhaka, Bangladesh. He has published more than 125 articles in reputed international and national journals
Abstract:
Objectives: As no studies were reported from Bangladesh, the present investigations were conducted on serum lipid profile, i.e. triglyceride TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoproteincholesterol (HDL-C) and lipoprotein (a) [Lp(a)] status in Bangladeshi patients with cholelithiasis and effects of laparoscopic cholecystectomy on them.
Patients & Methods: Adult patients (n=44) with cholelithiasis and normal controls (NC) (n=30) were included in the study. The blood samples were taken from fasting patients at diagnosis before cholecystectomy (Serum-I0), gall bladder bile during cholecystectomy (Bile- I0) and blood samples again after 2-3 months at follow-up (Serum-II0) and from fasting NC subjects.TG, TC, LDL-C and HDL-C were quantitated by standard methods and Lp(a) status by immunoturbidimetric method in serum and bile using research kits from reputed companies. The results were compared statistically by ANOVA, Student’s t-test and Chi-squared test using SPSS program.
Results: TG level was elevated in Serum- I0, Bile- I0 and Serum- II0 of patients, being highest in Bile- I0 compared to controls (NC) (p<0.001). TG level was reduced in serum -II0 after cholecystectomy compared to Serum- I0 and Bile- I0, although it remained significantly elevated compared to controls (NC) (p<0.001). TC level was elevated in Bile- I0 compared to Serum- I0 and Serum- II0 (p<0.001). Interestingly, TC was elevated in Serum- II0 after cholecystectomy, although no significant difference was observed between NC and patients Serum- I0 (p=0.835). LDL-C levels in NC, Serum- I0 and Serum- II0 were similar (p=0.126, p=0.121), although Serum-II0 levels was elevated compared to Serum- I0 (p<0.001) and it was much elevated in Bile- I0 (p<0.001). HDL-C levels were similar (p>0.05) among NC, Serum- I0 and Serum- II0, but it was higher in Bile- I0 significantly (p<0.001). Lp(a) (mg/dl) was much higher in patients compared to NC (Mean± SD: 29.07±14.17/NC, 290.84± 110.93/Serum-I0, 37.12±28.61/Bile-I0, 203.70± 90.13/ Serum-II0), (P< 0.001). Lp(a) was lowered after cholecystectomy, but remained elevated in patients Serum-II0 compared to NC significantly (P <0.001). No significant difference was observed for Lp(a) levels between NC and patients Bile-I0 (P = 0.173). The proportions of patients for Serum-I0, Bile-I0 and Serum-II0 with Lp(a) levels above and within normal limits and their statistical analyses showed significant associations (P<0.001)
Conclusion: Alterations in lipid profile and Lp(a) in cholelithiasis were significant but complex and laparoscopic cholecystectomy had profound effects on them indicating a special function of gall bladder relevant to their metabolism. The results were discussed accordingly.
Keynote Forum
Arjun Panesar; Charlotte Summers
Diabetes.Co.UK
Keynote: A Digitally Delivered Low-Carbohydrate Type 2 Diabetes Self-Management Program
Biography:
Charlotte Summers, BSc Psychology, charlotte@diabetes.co.uk
COO, Diabetes Digital Media
Charlotte is responsible for the creation and delivery of digital education programs with proven health outcomes and cost savings. With a background in psychology, Charlotte's passion and expertise lie in creating offline accountability and sustainable health behavioural change in a digital age.
Arjun Panesar, MEng Artificial Intelligence, arj@diabetes.co.uk.
Co-founder, Diabetes Digital Media
Arjun has a decade of experience with intelligent health systems and big data. Holding a Masters in Artificial Intelligence from Imperial College London, Arjun's focus is transforming healthcare through empowering patients - through the use of real-world big data and genomics.
Abstract:
Program Topic Areas:
1. Diabetes, obesity, metabolic health
2. Digital Health
3. Nutritional guidelines and best practice
Overview:
For the past few decades, diet and lifestyle programs for adults with type 2 diabetes have included recommendations to follow a low-fat diet, often using in-person programs. In
parallel, however, research has shown that carbohydrate-reduced diets may more effectively reduce body weight, improve glycemic control, and reduce hypoglycemic medications. Plus, online interventions have shown promise for encouraging these dietary changes. The Low Carb Program has combined these approaches, teaching a carbohydrate reduced, real-food way of eating to adults with type 2 diabetes supported by digital approaches enabling behaviour change and sustainable health improvements.
The goals of this talk are to:
(1) examine the preliminary efficacy of these carbohydrate-reduced digital interventions for reducing body weight, improving glycemic control, and reducing hypoglycemic medications in adults with type 2 diabetes.
(2) Highlight the efficacy of a digital intervention as a method of delivery and behavior change support. The presenters will talk about a commercially available digitally supported program that teaches a low-carbohydrate diet using online videos- and handout-based lessons, weight self-monitoring, dietary self-monitoring, digital social support groups, and medication management through the participants' own healthcare team. Results will be presented from a prospective longitudinal study. Overall, it is the presenters hope that the audience will be provided with new ways to think about diet and lifestyle interventions for adults with type 2 diabetes.
Learning Objectives:
- Learn how the Low Carb Program, a digital health intervention has been enabling adults with type 2 diabetes to implement a carbohydrate-reduced diet and lifestyle, in particular, understand how the components of this automated online low-carbohydrate program influence behaviour change
- Understand the potential impact of carbohydrate-reduced diets on weight loss, glycemic control, and medication reduction in adults with type 2 diabetes.
ABSTRACT
Background
Type 2 diabetes has serious health consequences including blindness, amputation, stroke, and dementia, and its annual global costs are more than $800 billion. Although typically considered a progressive, nonreversible disease, some researchers and clinicians now argue that type 2 diabetes may be effectively treated with a carbohydrate-reduced diet.
Objectives
Our objective was to evaluate the 1-year outcomes of a digitally delivered Low Carb Program (LCP), a nutritionally focused, 10-session educational intervention for glycemic control and weight loss for adults with type 2 diabetes. The program reinforces carbohydrate restriction using behavioral techniques including goal setting, peer support, and behavioral self-monitoring.
Methods
The study used a quasi-experimental research design comprised of an open-label, singlearm pre- and post-intervention using a sample of convenience. From adults with type 2 diabetes who had joined the program and had a complete baseline dataset, we randomly selected participants to be followed for 1 year (N=1000; mean age 56.1, SD 15.7, years; 59% (593/1000) women; mean HbA1c 7.8, SD 2.1, %; mean body weight 89.6, SD 23.1, kg; taking an average of 1.2 diabetes medications).
Results
Of the 1,000 study participants, 708 (70.8%) individuals reported outcomes at 12 months, 672 (67.2%) completed at least 40% of the lessons, and 528 (52.8%) completed all lessons of the program. Of the 743 participants with a starting HbA1c at or above the type 2 diabetes threshold of 6.5%, 195 (26.2%) reduced their HbA1c to below the threshold while taking no glucose-lowering medications or just metformin. Of the participants who were taking at least one hypoglycemic medication at baseline, 40.4% (289/714) reduced one or more of these medications. Almost half (46.4%, 464/1000) of all participants lost at least 5% of their body weight. Overall, glycemic control and weight loss improved, especially for participants who completed all 10 modules of the program. For example, participants with elevated baseline HbA1c (≥7.5%) who engaged with all 10 weekly modules reduced their HbA1c from 9.2% to 7.1% (P<.001) and lost an average of 6.9% of their body weight (P<.001).
Conclusions
Especially for participants who fully engage, an online program that teaches a carbohydratereduced diet to adults with type 2 diabetes can be effective for glycemic control, weight loss, and reducing hypoglycemic medications.
- Metabolic Syndrome | Cardiovascular Disorder | Insulin Resistance Syndrome | Obesity, Diabetes and Metabolism | Oxidative Stress and Inflammation | Managing stress
Location: Atlantis 2
Chair
Jun Sun
University of Illinois at Chicago, USA
Session Introduction
Brandon Davis
Davis Psychological Services, USA
Title: Metabolic Factor: A stable measure of biological predisposition for obesity
Biography:
Brandon Davis earned his Ph.D. in Counseling Psychology from Texas A&M University in 2004. He began performing bariatric surgery pre-operative evaluations in 2006 and has now done over 1,300 such assessments. In 2011, he expanded his services to provide therapy to people struggling with obesity. In 2013, he earned a certification in bariatric counseling from the American Association of Bariatric Counselors. He has published two studies in the field of bariatrics relating to Metabolic Factor, which is a method of assessing a biological predisposition for obesity.
Abstract:
A new metric called Metabolic Factor (Resting Metabolic Rate/Weight) has previously been established that can differentiate between people who are obese, overweight and of normal weight. Previous studies were re-analyzed and found that people who lost weight did not experience a change in their Metabolic Factor. The current study measured the Metabolic Factor of 18 individuals before and after bariatric surgery. As expected, individuals lost nearly 100 pounds and therefore lowered their Resting Metabolic Rate from 2,614.3 to 1,954.4 kcal (p < 0.05). However, the pre-operative Metabolic Factor of 8.1 (1.1) calories/pound did not change significantly as it slightly increased to 8.6 (0.88) after surgery (p = 0.19). Weight loss was not statistically significantly correlated with change in Metabolic Factor (r = 0.22). The follow up Metabolic Factor negatively correlated with post-operative BMI, r = -0.48 (p < 0.05), indicating the higher the Metabolic Factor, the lower the post-operative BMI. This study seems to establish the possibility that Metabolic Factor is not simply a function of one’s current weight, but instead might be a stable characteristic unique to each individual.
Hanan A Alfawaz
King Saud University, Saudi Arabia
Title: Dietary patterns and prevalence of metabolic syndrome in Saudi patients with diabetes and Ischemic Heart Disease
Time : 14:00-14:40
Biography:
Hanan A Alfawaz is associate professor at King Saud University, Saudi Arabia. She has published more than 30 papers in ISI journals with high impact factor. She has been a speaker in national and international conferences. She is a member in Prince Mutaib Chair in Osteoporosis. She is also a supervisor for Master and Ph.D. students and member in many committees.
Abstract:
Few studies have reported the relationship between diet and Metabolic Syndrome (MS). Our aim is to identify the predictors of MS among obese, diabetic and cardiac Saudi patients, and to find out the relationship between MS and dietary pattern. A cross-sectional study, 448 obese, diabetic and Ischemic Heart Disease (IHD) patients were participated. Questionnaire and multiple 24h dietary recall for three consecutive days were designed for this study. Biochemical indices of glucose, and lipids,anthropometric and BP were measured. The prevalence of MS among subjects using the criteria of modified National Cholesterol Education Program and Adult Treatment Panel III (mNCEP-ATP III) and International Diabetes Federation (IDF) were found to be 80.1% and 75.4% respectively. MS was significantly (p≤0.05) higher among male. According to the MnCEP-ATP III definition low HDL-C was the most common indicator of MS. Abdominal obesity was significantly (p≤0.05) higher in female. According to the IDF definition abdominal obesity was the most common indicator of the MS. There were a high consumption of cholesterol and saturated fatty acids and low consumption of polyunsaturated fatty acids among these patients. Significant relationships (p ≤0.05) were found between consumption of red meat, fast food and animal fats and presence of MS predictors. Significant relationships (p ≤0.05) were found between consumption of grain and grain products and legumes and higher triacylglycerol (TAG) level. The study includes some other relationships between MS and the dietary pattern. The prevalence of MS among these patients was extremely high, which supposed to be controlled by both medications and diet. Consumption of certain diet elements has strong relation to development of MS.
Jeffrey L Kibler
Nova Southeastern University, USA
Title: Development of a health behavior intervention for adults with PTSD
Biography:
Jeffrey L. Kibler completed his Ph.D. from the University of Miami and postdoctoral studies from the University of Mississippi Medical Centre. He is the director of the Biofeedback and Health Psychology Centre at Nova Southeastern University. He has more than 30 scientificp ublications and routinely serves as a grant reviewer for U.S. federal and Italian Ministry of Health proposals for research grant funding.
Abstract:
Post-traumatic stress disorder (PTSD), is a disorder of extreme stress/anxiety responses to a psychologically traumatic experience, has been associated with significantly greater incidence of heart disease and prevalence of metabolic syndrome. This higher risk for cardiovascular disease (CVD) in PTSD appears to be, in part, due to difficulties maintaining healthy lifestyles (e.g., weight management through healthy diet and regular physical activity, adequate sleep) and coping with daily stressors. The need for developing effective CVD prevention programs for adults with PTSD is increasingly evident. Therefore additional research is needed to examine programs that may reduce health risk behaviours and prevent early onset of CVD. The present project is a pilot study to examine whether a treatment program focused on healthy lifestyle behaviours (physical activity, good nutrition, sleep hygiene) and stress management will be associated with reductions in the levels of CVD risk variables (e.g., body weight, lipids, blood pressure) for adults with chronic PTSD and least one of the targeted health risks.This presentation illustrates the development of the intervention program, and the design of the study measurement. Results of preliminary cases will assist in determining whether targeting health behaviours as a novel component of PTSD treatment aids in reducing CVD risk.
Biswaroop Roy Chowdhury
Indo-Vietnam Medical Board, India
Title: Diabetes reversal by plant-based diet
Biography:
Biswaroop Roy Chowdhury is an Indian Medical Nutritionist, a post graduate in Diabetes Education and American Heart Association Certified Advance Cardiovascular Life Support Instructor. He is the author of 25 books, including the national bestseller, “Diabetes Type I and II Cure in 72 Hours”. He is also the founder president of Indo-Vietnam Medical Board and runs his flagship program, “3-Days Diabetes Cure Residential Tour” in Vietnam and India, focused towards Type I and insulin-dependent Type II patients. Presently, he is involved in his ambitious project “Diabetes Free World” and is preparing to launch his 26th book “Diabetes Free World” in 71 languages, aiming to break the World Record of a book published in most languages. His book will be launched on World Diabetes Day (November 14, 2017) which is also exactly the 100th year since the discovery of first diabetes medicine.
Abstract:
Diabetes leads to a never-ending medicine and or insulin treatment for the diseased. Our goal was to establish and observe the effects of plant-based diet on the sugar levels of the diabetes patients. The major portion of plant-based diet consisted of raw fruits and vegetables. The clinical trial on 55 diabetes patients with a team of 6 medical associates was practiced for 3-days at Zorba, The Buddha, 10 – Tropical Drive, Ghitorni, New Delhi from 29th April to 1st May, 2016.
Medicines were eliminated from the first day of the trial. Both fasting and post-prandial readings were measured each day along with the weights of the participants. The subjects with varying diabetes history, age groups, type of diabetes, insulin dependency and demographic profiles were part of the trial.
Through the trial, 84% of patients reported controlled blood glucose levels and 16% of patients reported partially-controlled levels. Those with controlled levels could attain a healthy blood glucose range without medicines and/or insulin, along with the prescribed diet in 3-days. Those with partially controlled levels could attain a healthy blood glucose range with less than 50% of insulin than prescribed earlier.
Among diabetes type-2 patients the study reported 100% results with all the patients maintaining a healthy blood glucose level. While among diabetes type-1 patients, 43% reported healthy blood sugar levels through the diet and insulin reduction. The weight reduction for 55 patients in 3-days was reported as 1.14kgs of average weight loss per individual. The plant-based diet has been found effective to cure and control diabetes, eliminating or reducing the medicine or insulin requirements.
- Nutrition and Metabolic Responses | Genetics of the Metabolic Syndrome | Cardiovascular Disorder | Weight Loss Therapies
Location: Atlantis 2
Chair
Christine Comera
National Institute of Agronomic Research (INRA), France
Session Introduction
Matej Stancik
Comenius University in Bratislava, Slovak Republic
Title: Vaspin – a novel predictor of coronary angiography result in SCAD (Stable Coronary Artery Disease) patients
Biography:
Matej Stancik is a research fellow at the Internal Medicine Dept. I., Jessenius Faculty of Medicine, Comenius University in Bratislava, Slovak Republic. He received his Doctor´s degree from Comenius University in Bratislava in 2010. He obtained his Ph.D. degree from the Comenius University in Bratislava in 2014. His doctoral research was devoted to the adipokine regulation in stable coronary artery disease. His postdoctoral research is dedicated to adipokine regulation in the situation of both acute and chronic ischaemic heart disease. He is the author of various research grants, including the SRDA (Slovak Research and Development Agency) grant APVV-14-0153 and the author and co-author of various research articles.
Abstract:
The roles of vaspin in the pathogenesis of stable coronary artery disease (SCAD) have been repeatedly addressed in clinical studies. In our study, data of 106 SCAD patients who received coronary angiography (CA) and 85 healthy controls were analysed. The patients were divided into subgroups according to their pre-test probability (PTP) and the result of CA. Fasting vaspin was compared between subgroups of SCAD patients and between target group and controls. The effect of age and smoking on the result of coronary angiography was compared to the effect of vaspin using the binomial regression. We did not find significant difference in vaspin level between target group and controls. Unless the PTP was taken into account, we didn´t find vaspin difference in the target group, when dividing patients on the basis of presence of significant coronary stenosis. In the subgroup of patients with PTP 15% - 65 %, those with stenoses had higher vaspin (0,579 ± 0,898 ng/ml) than patients without significant stenoses (0,379 ± 0,732 ng/ml) t = -2,595; p = 0,012; d = 0,658; 1-β = 0,850. Age, smoking and vaspin contributed to the prediction of coronary stenosis in binomial regression model in low PTP (OR: 1.1, 4.9, and 8.7 respectively). According to our results, vaspin can´t be used as an independent marker for the presence of SCAD. Vaspin measurement might be clinically useful in patients with PTP below 66 %. This study was supported by the SRDA grant APVV – 14 – 0153 and by the VEGA grant 1/0160/16.
Jiang He
Tulane University, USA
Title: The design and rationale of a cluster randomized trial testing the effect of a collaborative care intervention on metabolic risk factors and cardiovascular events: Diabetes Complication Control in Community Clinics (D4C) Trial
Biography:
Jiang He is a professor and Joseph Copes Chair of Epidemiology at the Tulane University School of Public Health and Tropical Medicine. He is also the Director of the Tulane University Translational Science Institute in New Orleans. He is an internationally well-known expert in the clinical, translational, and epidemiological research of cardio-metabolic diseases. He has conducted novel, NIH-funded studies in obesity, hypertension, diabetes, stroke, and cardiovascular disease. He has been the principal investigator and co-investigator for more than 30 major research awards from the NIH. Additionally he has authored more than 400 scientific articles which have been published in high-impact biomedical journals.
Abstract:
Most patients with diabetes have multiple uncontrolled metabolic risk factors. The overall objective of this cluster randomized trial is to test whether a collaborative care intervention will improve metabolic risk factors (glycated haemoglobin [HbA1C], systolic blood-pressure [SBP], and LDL-cholesterol) over 18 months (primary outcome in phase 1) and reduce major cardiovascular disease (CVD) over 3 years (primary outcome in phase 2) among patients with type-2 diabetes and increased CVD risk in China. The collaborative care intervention will be delivered by a team of primary care physicians, health managers, and nurses supported by diabetes specialists. The multicomponent interventions include health coaching for lifestyle modification and medication adherence and a decision support system using a stepped-care protocol for managing diabetes, hypertension, and dyslipidaemia based on clinical guidelines. The D4C trial will recruit 11,780 patients with diabetes and increased CVD risk from 38 community clinics in Xiamen, China. Nineteen clinics with approximately 310 patients each will be randomly assigned to intervention and 19 clinics to control. Study outcomes will be obtained at follow-up visits every 6 months. The D4C trial is designed to provide 90% statistical power to detect a 3.6% reduction in the combined changes in HbA1C, SBP, and LDL-cholesterol levels in phase 1 and a 20% reduction in major CVD in phase 2 at a significance level of 0.05 for a two-sided test. This trial will generate important data on an effective, practical and sustainable intervention program aimed at reducing the CVD burden among diabetes patients in populations with health disparities.
Daniel Roberto Magdaleno Rodriguez
National Polytechnic Institute, Mexico
Title: Efficiency and safety of Anfepramona in the treatment in patients with obesity
Biography:
Daniel Roberto Magdaleno Rodriguez is Mexican medical student of Superior School of Medicine (School of Medicine) at National Polytechnic Institute. He is a junior researcher who has been working at the obesity center of the School since 2013 on different research lines regargding obesity, diabetes, fatty liver, metabolic syndrome and hypertension. His most important recent research is focused on drug effectiveness and security for obesity and fatty livertreatment. He is also founder and CEO of AIMEDS A.C.
Abstract:
Obesity has become a public global health, we can not lose sight that this disease has reached epidemic global proportions, which is why the World Health Organization (WHO by the acronym in English) calls obesity as the epidemic of the century. The purpose of this study was to evaluate the efficacy and safety of anfepramona in patients with obesity against patients who recieve a placebo. It was a longitudinal, prospective and comparative study during 6 months. This study was conducted under 200 exogenous obese patients, aged between 18 and 60 years of both sexs with Body Mass Index (BMI by the acronym in English) between 30 and 45 kg/m2 Patients were randomized into two groups of 100 subjects each and were administered for six months with anfepramona (group 1) or placebo (group 2). All patients were under medical supervision during the six months of treatment and baseline blood determinations of glucose, total cholesterol, HDL and LDL, triglycerides and liver enzymes were made, these determinations were also made at the end of the study and compared with the initial figures, results were obtained Significant in different variables.