Animal Models of Metabolic Syndrome

Metabolic syndrome (MetS) consists of several medical conditions that collectively predict the risk for cardiovascular disease better than the sum of individual conditions. The risk of developing MetS in human depends on synergy of both genetic and environmental factors. Being a multifactorial condition with alarming rate of prevalence nowadays, establishment of appropriate experimental animal models mimicking the disease state in humans is crucial in order to solve the difficulties in evaluating the pathophysiology of MetS in human. Metabolic syndrome has been defined as a group of risk factors that directly contribute to the development of cardiovascular disease and/or type 2 diabetes. Insulin resistance seems to have a fundamental role in the genesis of this syndrome. Over the past years to the present day, basic and translational research has used small animal models to explore the pathophysiology of metabolic syndrome and to develop novel therapies that might slow the progression of this prevalent condition.

  • Diet-induced models of Metabolic Syndrome
  • Tools and Tests
  • Cardiovascular Changes in Animal Models of Metabolic Syndrome
  • Characterization and its Application
  • Challenges and Complications
  • Genetic models of MetS
  • Drug/chemically-induced model of MetS
  • Other animal models of MetS

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